硕士研究生指导教师简介 |
姓 名 |
罗钢银 |
|
性 别 |
男 |
出生年月 |
1983.10 |
最高学历、学位 |
博士研究生、博士 |
职 称 |
研究员 |
职 务 |
|
电子邮箱 |
luogy@sibet.ac.cn |
一、基本情况：
罗刚银，博士，研究员，博士生导师，工程化研究中心副主任，国家创新医疗器械审评专家，苏州电子协会副理事长。长期从事器官再生、光学成像、图像处理/人工智能算法等方向的研究。
近年来作为项目负责人和课题负责人承担了20余项国家及企业课题的研究，包括国家重点研发计划子课题、国家科技支撑计划项目、国家863项目子课题、中科院先导A类项目、江苏省科技支撑项目、苏州市医疗器械专项、企业委托项目等。
二、主要研究领域及学术成就：
1．器官再生方向：构建基于肿瘤和iPSC的脑、心、肝和肿瘤类器官体系及其药筛应用研究；开展器官再生所需水凝胶、生物活性材料、结构支撑材料研究；类器官长时程功能维持与多模传感检测技术；体外肝脏常温机械灌注维持与再生技术。
2．光学成像方向：开展提升显微成像分辨率、成像速度及成像维度研究，包括高速振镜扫描控制、多波长激光耦合、近红外光谱分析、超分辨显微成像、图形三维重建等研究。
3．医学检验方向：长期从事医学检验仪器的自主创新与国产化研究，涉及免疫、分子和细胞等领域的微弱荧光检测、机械手、变温调控、图像识别、定位离心、智能控制与AI算法等。
4．图像处理/人工智能算法方向：聚焦深度学习与计算机视觉、深度学习与生物样本成像分析、细胞与类器官的人工智能图像处理算法等研究工作。
累计申请发明专利80项，授权发明专利25项，授权实用新型专利58项。在Lab on a Chip、Talanta、光学精密工程等发表论文30篇，获批II类医疗器械注册证4项。获苏州市科技进步奖、苏州市好青年荣誉称号。
三、代表性科研成果：
承担项目情况
1．国家重点研发计划，全自动智能化高精度荧光检测系统的研究，课题负责人，2020.5-2023.4，结题
2．国家重点研发计划，多孔腔镜手术机器人可靠性设计与系统集成，子课题负责人，2017.7.1-2021.12.31，结题
3．国家重点研发计划，手术机器人安全性与有效性评估体系研究，子课题负责人，2019.12.1-2022.11.1，结题
4．国家科技支撑计划，肿瘤靶向治疗的病理诊断及疗效评估免疫分析系统的研制，子课题负责人，2015 .1-2017.12，结题
5．中科院先导A类项目，器官长时程功能维持与监测，课题负责人，2021.11-2022.12，结题
6．中科院重大科研设备，超分辨显微光学核心部件工程化开发，项目负责人，2018.1.1-2022.12.31，结题
7．江苏省科技支撑计划，基于血型免疫学方法的自动化专用仪器关键技术研究及产业化，2013.6-2016，结题
8．吉林省院地合作专项，基于数字微滴技术的核酸检测系统及通用试剂的产业化，项目负责人，2020.1-2022.6，结题
9．江苏省科技支撑计划，基于血型免疫学方法的自动化专用仪器关键技术研究及产业化，2013.6-2016，结题
10．苏州市新冠应急专项，基于恒温CRISPR法的系列化核酸检测仪器的研制，2020.3.1-2020.12.31，结题
代表论著
1．Feng, Ruijie; Li, Zeqin; Zhu, Junyan; Zhang, Yayun; Fang, Hao; Xue, Jinbing; Wang, Jinxian; Lyu, Renliang*; Luo, Gangyin*, Synthesis of a biocompatible fluorinated multiblock copolymer surfactant for water-in-fluorocarbon droplets and its application in droplet digital polymerase chain reaction, JOURNAL OF APPLIED POLYMER SCIENCE, 2024.
2．Zhang, Xiaoliang; Wang, Shun; Wang, Jinxian; Sun, Xiaojie; Xue, Jinbing; Wang, Zhenya; Yang, Tianhang; Weng, Liangfei; Wang, Bidou*; Luo, Gangyin*, A ddPCR platform based on a microfluidic chip with a dual-function flow-focusing structure for sample-to-result DNA quantification analysis, LAB ON A CHIP, 2023.
3．Leng, Bing; Jiang, Hao; Wang, Bidou; Wang, Jinxian; Luo, Gangyin*, Deep-Orga: An improved deep learning-based lightweight model for intestinal organoid detection., Computers in biology and medicine, 2023.
4．Wang, Jinxian; Lyu, Xin; Zhang, Xiaoliang; Wang, Shun; Zeng, Wen; Yang, Tianhang*; Wang, Bidou*; Luo, Gangyin*, An approach for integrating droplet generation and detection in digital polymerase chain reaction applications based on a bifunctional microfluidic cross-structure, TALANTA, 2024.
5．Luo, Gangyin; Zhang, Ying; Wang, Shun; Lv, Xinbei; Yang, Tianhang*; Wang, Jinxian*, Establishment and Validation of an Integrated Microfluidic Step Emulsification Chip Supporting Droplet Digital Nucleic Acid Analysis, BIOSENSORS-BASEL, 2023.
6．Li, Zeqin; Ma, Houshi; Guo, Yuxin; Fang, Hao; Zhu, Chunsen; Xue, Jinbin; Wang, Wenzhong; Luo, Gangyin*; Sun, Yi*, Synthesis of uniform Pickering microspheres doped with quantum dot by microfluidic technology and its application in tumor marker, TALANTA, 2023.
7．Zhang, Xiaoliang; Wang, Jinxian; Lyu, Xin; Yang, Tianhang; Liu, Wei; Wang, Bidou*; Luo, Gangyin*, Hundred-micron droplet ejection by focused ultrasound for genomic applications, SENSORS AND ACTUATORS A-PHYSICAL, 2023.
8．Feng, D.; Zhou, C.; Huang, J.; Luo, G*.; Wu, X., Design and Implementation of Gesture Recognition System Based on Flex Sensors, IEEE Sensors Journal, 2023.
9．Liu, H.; Luo, G*., High frequency heat sealing system in-situ power detection device, 2023 2nd International Symposium on Sensor Technology and Control (ISSTC), 2023.
10．Ma, Xiaoyi; Li, Xiaoqiang; Luo, Gangyin*; Jiao, Jin*, DNA-functionalized gold nanoparticles: Modification, characterization, and biomedical applications, FRONTIERS IN CHEMISTRY, 2022.
11．Yang, Tianhang; Wang, Jinxian; Lv, Sining; Li, Songjing*; Luo, Gangyin*, Thermodynamic Characterization of a Highly Transparent Microfluidic Chip with Multiple On-Chip Temperature Control Units, CRYSTALS, 2022.
12．Li, Xiaoqiang; Guo, Zhenzhen; Luo, Gangyin; Miao, Peng*, Fluorescence DNA Switch for Highly Sensitive Detection of miRNA Amplified by Duplex-Specific Nuclease, SENSORS, 2022.
13．Xue, Yuhan; Luo, Gangyin; Liu, Xiang; Xing, Yuan*; Hu, Bo; Liu, Zhenglong, An Analysis on the Engineering Failure of the Wire Rope Used in Surgical Instruments, JOURNAL OF FAILURE ANALYSIS AND PREVENTION, 2022.
14．Zhou Minchao; Wang Zhenya*; Wang Bidou; Luo Gangyin; Ma Siqi, Design of laser scanning confocal spectroscopy system, Optics and Precision Engineering, 2022.
15．Zhang, Jia-Hao; He, Da-Yong; Luo, Gang-Yin; Wang, Bi-Dou; Huang, Jin-Song*, Bidirectional highly-efficient quantum routing in a T-bulge-shaped waveguide*, CHINESE PHYSICS B, 2021.
16．Zhang, Jie; Yan, Jiaqi; Wang, Jinxian; Xu, Jie; Zhao, Yilong; Luo, Gangyin*, Research on Droplet Digital PCR Amplification System, 2021 IEEE 20TH INTERNATIONAL CONFERENCE ON TRUST, SECURITY AND PRIVACY IN COMPUTING AND COMMUNICATIONS (TRUSTCOM 2021), 2021.
17．Zhang, Xiaoliang; Wang, Bidou; Luo, Gangyin, Design of Dyson Flow Cytometry System, Chinese journal of medical instrumentation, 2019.
18．Luo Gangyin; Wang Bidou; Chen Yugi; Zhao Yilong, Design of athermal mid-infrared imaging spectrometer based on Offner scheme, Infrared and Laser Engineering, 2017.
19．Luo Gangyin; Wang Bidou; Chen Yuqi; Zhao Yilong, Design of Visible Near Infrared Imaging Spectrometer on Unmanned Aerial Vehicle, Acta Photonica Sinica, 2017.
20．Wang Lei; Nie Lan-shun; Zhan De-chen; Wang Bi-dou; Luo Gang-yin, Heuristic algorithm for solving multi-project collaborative scheduling problem with activity splitting, Control and Decision, 2017.
21．Luo Gangyin; Wang Bidou; Chen Yuqi; Zhao Yilong, Optical design of confocal system for near infrared fluorescence scanning, Laser and Infrared, 2017.
发明专利
22．罗刚银、王弼陡、陈月岩、张运平，一种基于灰度分析与种类识别的血型结果识别算法，发明专利，ZL 201310416614.3
23．罗刚银、王弼陡、徐昊、王磊、刘亮，张运平，具有卡盒位姿调整机构的血型卡离心机，发明专利，ZL 201510906311.9
24．罗刚银、吕鑫、杨天航、王弼陡、赵义龙，王进贤，一种用于离体器官灌流的恒温容器，发明专利，ZL 202310171771.6
25．罗刚银、王弼陡、徐昊、王磊、刘亮、张运平，具有卡盒位姿调整机构的血型卡离心机，发明专利，ZL 201510906311.9
26．罗刚银、杨天航、王进贤、王弼陡、吕鑫、赵义龙，一种用于器官体外培养和再生的机械灌注系统，发明专利，ZL 202310170168.6
27．罗刚银、王弼陡、徐昊、王磊、刘亮、张运平，具有自动开盖机构的孵育机构，发明专利，ZL 201510903573.X
28．罗刚银、王进贤、刘亮、赵义龙、黄杰、史奉鑫，一种移动扩增底座的
